Passionate about precision medicine and advancing the healthcare industry?

Recent advancements in underlying technology have finally made it possible for AI to impact clinical care in a meaningful way. Tempus' proprietary platform connects an entire ecosystem of real-world evidence to deliver real-time, actionable insights to physicians, providing critical information about the right treatments for the right patients, at the right time.

We are looking for a highly skilled Research Scientist to join our Biological Modeling team to support Organoid Based Screening and patient-derived models. Our CAP accredited facility develops human tumor models for use in a range of studies with our academic and commercial partners to discover next generation cancer therapies. The ideal candidate will have a strong understanding of immuno-oncological cell therapies, systems biology, FACS/FLOW, protein detection and scSeq techniques. Post-doctoral and/or industry experience employing disease relevant 3D tissue models, tissue/tumor slice or human organoid tumor models to support drug discovery at scale is strongly preferred.

The successful candidate must be able to work in a fast-paced multidisciplinary environment, matrixed teams and communicate results both internally and to commercial partners.

What You’ll Do:

• Work with a team of passionate scientists and research technicians/ associates to implement organoid-based assays using an automated, high throughput platform
• Design and execute patient-derived tumor modeling with drug screening and imaging workflows
• Design and execute experiments incorporating other NGS based technologies such as scSEQ, WES, WGS, epigenetics, and WTS
• Integrate and interrogate multimodal data (genomics, drug screening, imaging) to draw biological insights
• Analyze data using biological and statistical software such as Flowjo, Excel, Prism
• Work with automated liquid and plate platforms at all stages of development
• Collaborate with cross-functional teams and contribute in matrix-based project groups
• Maintain laboratory notebooks and follow laboratory practices in compliance
• Generate summary reports of screening results for customer deliverables.

Qualifications:

• Ph.D. in oncology, molecular systems biology or a related field
• 2+ years of industry or post-doctoral experience
• Experience with 3D human tissue models
• Experience with cellular immunotherapies is required, including primary 3D and slice cell culture, immune cell activation/expansion, scRNAseq and high-throughput screening
• Experience in vitro immune cell characterization and functional assessment, such as, flow-based immunophenotyping, multiplex cytokine measurements
• Experience coordinating complex experimental workflows across multidisciplinary teams.

Benefits:

• Competitive salary and benefits package
• Collaborative and supportive work environment
• Chance to make a real impact on the healthcare industry

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